His commercial ventures include Umnai, Intralot Bit8, and Q-Free Traffiko (rendered as Q-Free Traffic in Portuguese Wikipedia). His awards include a Bronze Medal at the 1995 International Olympiad in Informatics and receiving the Malta Top Entrepreneur award in both 2014 and 2019.^[2,3,4] Dalli is featured in a 2018 headshot photograph and publishes content on Medium.

Dalli was born in Malta and grew up in the town of Birżebbuġa. Dalli was educated at the Archbishop's Seminary in Malta and represented Malta in the Young European Environmental Research contest held in Cologne in 1994. He also represented Malta in the International Olympiad in Informatics held in Eindhoven in 1995, where he won a bronze medal.^[4,5] He went on to study at the University of Malta and the University of Sheffield. Dalli started selling computer software as a teenager and worked for the International Data Group as a freelance contributor for PC World.^[7,54] He is a member of the Association for Computing Machinery, the Institute of Electrical and Electronics Engineers, the Association for the Advancement of Artificial Intelligence, and the Association for Computational Linguistics.

After graduating from the University of Malta, Dalli spent time lecturing on artificial intelligence and natural language processing before pursuing his doctorate at the University of Sheffield under the supervision of Yorick Wilks.^[8] Dalli has published over 23 peer-reviewed papers according to English Wikipedia (or more than 20 according to Portuguese Wikipedia) in the fields of artificial intelligence and natural language processing, including one of the earliest methods on timestamp extraction from documents that is now commonly used in most email applications.^{[9,10,11,12,7]} Angelo has also contributed to the encoding of European languages in Unicode, in particular for the Common Locale Data Repository.^[13] In the field of bioinformatics, Dalli found a particularly useful integer sequence (sequence A062208 in the OEIS) which efficiently computes all alignments of strings of length 3 together with other generalizations (sequences A062204 and A062205 in the OEIS) for applications in natural language and sequence alignment. Dalli has an Erdős number of 3.^[14] Dalli has led the Maltese national informatics team in the International Olympiad in Informatics at IOI 2002 in Seoul, South Korea and IOI 2004 in Athens, Greece.^[4,3]

Angelo has been a vocal proponent and advocate of trustworthy and ethical AI that impacts society positively and believes that AI should be properly regulated.^[15] He co-founded UMNAI in 2019, with the aim of creating a new form of trustworthy AI that can explain the decisions and steps that the AI has taken to output an answer, based on a neurosymbolic AI architecture that combines neural and symbolic AI in an auditable and certain manner.^{[21,17,18,19]} Angelo was appointed by the Government of Malta to the working group that produced the new AI regulations and Malta's national AI strategy, and is an active member of AAAI, ACM, and ACL.

Angelo led the introduction of various machine learning techniques in intelligent transport systems (ITS), including parking, controlled vehicle access zones, and dynamic traffic interchange control.^[25,22,23] His intelligent transport company, Traffiko, operated in Europe, Australia, and the Middle East, and was eventually sold to Q-Free in Norway in 2015.^[26,24]

Angelo is a well-known speaker in the online gambling industry.^{[27,30,31,28]} He set up one of the first companies that applied artificial intelligence in the online gambling industry, called Bit8 (now part of Intralot), with its most notable work focusing on algorithms that estimate and maximize player lifetime value as well as personalized bonusing systems.^[29] These techniques have since been widely adopted across the online gambling industry, and Intralot subsequently acquired Bit8 in 2017.^[32]

Angelo has collaborated with various artists and creatives to teach artificial intelligence about creativity, leading to the creation of the UMA (Universal Machine Artist) AI entity. UMA creates original artwork using a modified Generative Adversarial Network that incorporates a third component—the human artist—to produce different learning results than standard generative AI models.^[33] Its underlying discriminator originated from an anti-fraud detection system and has gradually evolved to include stable diffusion and procedural generation methods.^[35] The first two artworks generated by UMA were auctioned in October and November 2018, respectively, with all proceeds donated to charity and good causes.^{[36,37,38,34]} Notable exhibitions include Tomorrow's Blossoms with Selina Scerri at Esplora Museum in 2024, which explored the theme of AI and emotions.^[39] Ongoing work continues to improve UMA and expand collaborations with other artists. Angelo has also co-founded the Creative Science and Arts Institute to serve as a foundation for future research into AI, science, technology, and creativity.

Angelo is an angel investor active in the high-tech startup scene, a member of EBAN, and a senator of the World Business Angel Forum.^[43] He has been encouraging Maltese startups through various public events, including the Zest and Budding Rockstars conferences, and co-founded BAM, the Malta Business Angel network, in 2019.^[46,42,44]

Intralot Bit8 received the EGR Rising Star Award in 2014, followed by the Malta Communication Authority eBusiness Award for the Best B2B application in 2015. In 2017, the company was awarded the Malta iGaming Award for Excellence.